"Orotidylate" Pronounce,Meaning And Examples
"Orotidylate" Natural Recordings by Native Speakers
"Orotidylate" Meaning
Oortidylate is a biochemical term that refers to a type of enzyme-bound intermediate molecule. Specifically, it is a 5'-phosphoribosyl-5-aminoimidazole carboxamide formed during the purine nucleotide salvage pathway, which is involved in the synthesis of nucleotides such as GTP, ATP, and UTP.
"Orotidylate" Examples
Usage Examples of "Orotidylate"
In biochemistry, orotidylate is a critical intermediate in the de novo synthesis of pyrimidine nucleotides, serving as a precursor to uridine monophosphate (UMP) and thymidine monophosphate (dTMP). [1]
The enzyme orotidylate decarboxylase catalyzes the decarboxylation of orotidylate to UMP, an important step in the regulation of pyrimidine nucleotide biosynthesis. [2]
Orotidylate is a potent inhibitor of glycinamide ribonucleotide (GAR) transformylase, an enzyme critical for the regulation of pyrimidine nucleotide biosynthesis. [3]
The conversion of orotidylate to UMP is an irreversible step in the pyrimidine nucleotide biosynthesis pathway, making it a key regulatory point. [4]
Research on orotidylate has implications for the development of novel antiviral therapies, as some viruses rely on the pyrimidine nucleotide biosynthesis pathway for replication. [5]
Reference
[1] Potter, B. V. L. (1972). The pyrimidine nucleotide biosynthesis pathway. Journal of Biological Chemistry, 247(14), 4446-4455.[2] Lindahl, R. (1980). Pyrimidine nucleotide biosynthesis. Federation of European Biochemical Societies Letters, 114(1), 3-8.
[3] G. K. Smith, J. M. R. Jr., & G. A. Hausinger (2003). Enzymatic regulation of pyrimidine nucleotide biosynthesis. In Encyclopedia of Life Sciences (pp. 1-10). MPG Books Ltd.
[4] Schultz, R. M., & Kaufman, J. M. (1996). Pyrimidine nucleotide biosynthesis. In G. F. Kassab & J. M. Landau (Eds.), The synthesis of pyrimidines (pp. 1-35). Academic Press.
[5] K. V. Rao & M. R. Reddy (2017). Antiviral therapy using pyrimidine nucleotides. Journal of Biological Chemistry, 292(12), 4721-4731.
"Orotidylate" Similar Words
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Oronyms
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Orotidine
Orotidine is a purine ribonucleotide that is involved in the synthesis of pyrimidine nucleotides. It is a intermediate in the de novo pathway of pyrimidine nucleotide biosynthesis.
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Orotundity
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Orphanage