"Orotidine" Pronounce,Meaning And Examples

"Orotidine" Meaning

Orotidine is a purine ribonucleotide that is involved in the synthesis of pyrimidine nucleotides. It is a intermediate in the de novo pathway of pyrimidine nucleotide biosynthesis.

"Orotidine" Examples

Examples of "Orotidine" usage:

Scientific context:

In biochemistry, orotidine is a pyrimidine base that is involved in the synthesis of nucleotides and nucleic acids. 1
Orotidine mono-phosphate decarboxylase is an enzyme that catalyzes the conversion of orotidine monophosphate to uridine monophosphate. 2

Medical context:

A deficiency in the enzyme dihydroorotase can lead to an accumulation of orotidine in the blood, causing a condition known as orotic aciduria. 3
In certain genetic disorders, the metabolism of orotidine is impaired, resulting in impaired pyrimidine synthesis. 4

Research context:

In a study on gene expression, the researchers analyzed the regulation of orotidine metabolism in response to environmental stress. 5
The enzyme orotidine-5'-phosphate decarboxylase was found to be essential for the growth of certain microorganisms, and its regulation was studied in detail. 6