"Sumoylation" Pronounce,Meaning And Examples
"Sumoylation" Natural Recordings by Native Speakers
"Sumoylation" Meaning
Sumoylation is a post-translational modification (PTM) of proteins, where a small ubiquitin-like modifier protein (SUMO) is covalently attached to a lysine residue on a target protein. This process is reversible, involving an isopeptidase called SENP (Sentrin/SUMO-specific protease).
During sumoylation, a SUMO protein molecule (approx. 100 amino acids long) is transferred to a lysine side chain of the target protein through an isopeptide bond. The attachment of SUMO to a protein can have various functions, including:
1. Regulation of protein activity: Sumoylation can activate or inhibit the activity of a protein. For example, sumoylation can inhibit the activity of certain transcription factors or regulate the activity of DNA repair enzymes.
2. Protein-protein interactions: Sumoylation can facilitate or disrupt protein-protein interactions by modifying the binding properties of a protein. Sumoylation can also create a binding site for other proteins, which can then recognize the sumoylated protein.
3. Protein localization and targeting: Sumoylation can affect the localization of a protein within the cell. For example, sumoylation can target a protein to a specific subcellular compartment or membrane.
4. Cellular responses to stress: Sumoylation can play a role in cellular responses to stress, such as the heat shock response or DNA damage.
5. Regulation of gene expression: Sumoylation can influence the expression of genes by modifying the activity of transcription factors or other regulators of gene expression.
Sumoylation has been implicated in many biological processes, including:
Development and differentiation
Cell growth and proliferation
Response to stress and DNA damage
Viral infection and cancer
Neurological diseases
Dysregulation of sumoylation has been linked to various diseases, including cancer, neurodegenerative disorders, and developmental disorders.
"Sumoylation" Examples
Sumoylation Examples:
1. Medical research: "The study on protein sumoylation unveiled new insights into its role in cancer development, revealing potential therapeutic targets."
2. Scientific jargon: "The post-translational modification of proteins through sumoylation affects their localization, function, and interaction with other molecules."
3. Academic paper: "Our research on sumoylation in plants shows that this post-translational modification is crucial for plant stress responses and resistance to pathogens."
4. Technical documentation: "Theprotein database includes a section on sumoylation, detailing the sumoylation sites and their corresponding effects on protein function."
5. Biotechnology applications: "The development of sumoylation inhibitors may lead to new treatments for neurodegenerative diseases by preventing protein misfolding and aggregation."
"Sumoylation" Similar Words
Summoning
The act of asking or commanding someone or something to appear or come, especially from a distant place. It can also refer to the act of calling upon a supernatural force, spirit, or entity to appear or exert its power. In various contexts, it can also mean the act of bringing someone or something into being, existence, or activity.
Summons
A formal notice or command to appear at a specific time and place, typically in a court of law or for a formal inquiry.
Summonses
Summonses refer to written requests or orders issued by a court or authorized individual to appear before a court or tribunal as a defendant or witness in a legal proceeding. They are often issued in cases where a person has been accused of a crime or is required to provide testimony.
Sumner
Sumner can refer to:<br><br>1. Sumner (unit) - a unit of time equal to 60 seconds.<br>2. Sumner (name) - a surname of English and Scottish origin.<br>3. Sumner (department store) - a now-defunct American department store chain.<br>4. Sumner County: <br> - Sumner County, Kansas, USA<br> - Sumner County, Tennessee, USA<br> - Sumner County, Utah, USA<br><br>A notable person:<br>- Charles Sumner (1811–1874), American politician and abolitionist.<br>- John Sumner (1904-1990), English footballer.<br>- John Bird Sumner (1780-1862), English churchman and Archbishop of Canterbury.<br>- Langston Hughes's poem "Sumner" was praising him.
Sumo
Sumo is a style of professional wrestling or sport from Japan that originated in the 16th century. It is traditionally performed in a circular ring called a "dohyo" by two or more wrestlers, known as "rikishi", who are trying to force their opponent out of the ring or make them touch the ground. The sport is known for its strong cultural and spiritual significance in Japan, with the largest sumo tournament, called the "Honbasho", held annually in Tokyo.
Sumoist
A sumoist is a slang term that refers to someone who is obsessed with or excessively enthusiastic about the sport of sumo wrestling.
Sumoylate
The word "sumoylate" is a verb that means to modify or regulate the activity of a protein by adding a small ubiquitin-like modifier, specifically a small ubiquitin-like modifier protein, or SUMO.
Sump
A depression in the ground that collects a flood of water when a sewer or other system is stopped up.
Sumps
Sumpter
Sumptuary
Having to do with luxurious or elegant living; concerned with the regulation of luxury, especially in dress and food.<br><br>Example: "Sumptuary laws were introduced to regulate the luxurious attire of the nobility."<br><br>Synonyms: luxurious, opulent, extravagant.
Sumptuosity
Extravagance or luxuriousness, typically in a way that is considered excessive or ostentatious.
Sumptuously
Sumptuousness
The quality or state of being excessively luxurious, elegant, or refined, characterized by a rich and elaborate style, often to an excessive or ostentatious degree.