"Rofecoxib" Pronounce,Meaning And Examples
"Rofecoxib" Natural Recordings by Native Speakers
"Rofecoxib" Meaning
Rofecoxib, also known as Viox, is a non-steroidal anti-inflammatory drug (NSAID) that was used to reduce the risk of pain and inflammation in patients with arthritis and other painful conditions. It was typically taken orally in the form of a capsule.
Rofecoxib works by selectively blocking the production of a specific enzyme called COX-2 (cyclooxygenase-2), which is involved in inflammation. By blocking COX-2, rofecoxib reduced the production of prostaglandins, which are hormone-like substances that cause pain and fever.
However, in 2004, the use of rofecoxib was halted due to concerns that it may increase the risk of heart attack and stroke, particularly in patients who took it for an extended period. As a result, the U.S. Food and Drug Administration (FDA) warned against using rofecoxib, and it was eventually withdrawn from the market.
It's worth noting that the controversy surrounding rofecoxib led to increased scrutiny of the role of COX-2 inhibitors in heart health and a broader debate about the benefits and risks of NSAIDs.
"Rofecoxib" Examples
RoFEcoxib Usage Examples
Medical
RoFEcoxib is a non-steroidal anti-inflammatory drug (NSAID) that was prescribed to treat pain and inflammation in patients with osteoarthritis and rheumatoid arthritis.
Due to serious side effects, rofecoxib was withdrawn from the market in 2004.
Clinical trials for rofecoxib were halted due to increased risk of cardiovascular events and other adverse reactions.
Researchers sought to find a safer alternative to rofecoxib for managing pain and inflammation.
Physicians had previously prescribed rofecoxib for patients with dysmenorrhea and menstrual cramps.
Scientific
A study compared the efficacy of rofecoxib with ibuprofen in treating patients with moderate to severe osteoarthritis.
Researchers tested the local and systemic anti-inflammatory effects of rofecoxib in animal models.
The clinical pharmacology of rofecoxib was analyzed to determine its safety and bioavailability in humans.
To evaluate the efficacy and safety of rofecoxib, researchers conducted a systematic review of double-blind randomized controlled trials.
Preclinical studies suggested that rofecoxib may have anticancer properties.
News
The FDA issued a warning about the potential risks associated with rofecoxib, which was approved for marketing in 1999.
Pharmaceutical companies faced significant financial losses after rofecoxib was discontinued.
A key study about the cardiovascular risks of rofecoxib was published in a leading medical journal.
When the rofecoxib issue developed, public awareness was raised about the intensive vetting of the safety of new pharmaceutical drugs.
In response to the revelations about rofecoxib, regulatory agencies began to alter their evaluation of drugs before release to the public.
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An roentgenometer is an early type of device used to measure exposure to X-rays. It was essentially an ionization chamber that measured the ionizing effect of ionizing radiation. The device was invented by the German physicist Wilhelm Conrad Röntgen in 1896, for whom the Ur-unit of exposure, the roentgen, is named. The roentgenometer consisted of an evacuated glass bulb that contained a metal cylinder with a layer of iodized air. The cylinders had a thin metal wire connected to an electrometer, which measured the electric charge developed when X-rays entered the bulb.
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A common male given name of Germanic origin, derived from the Scandinavian name "Hroger," which is composed of two elements: "hroth," meaning "fame" or "renown," and "ger," meaning "spear." The name Roger is also a shortened form of Rogerius or Rogerus, medieval names that were popularized by the Norman Conquest of England.