"Riluzole" Pronounce,Meaning And Examples

"Riluzole" Meaning

Riluzole is a medication used to treat amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or motor neuron disease. It is an amino acid derivative that is believed to slow the progression of ALS by blocking the release of excitatory neurotransmitters, such as glutamate, which can be toxic to nerve cells.

"Riluzole" Examples

Usage Examples for Riluzole

Example 1: Medical Context

Riluzole tablet is used in the treatment of Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease.
According to research, the benefits of riluzole in extending the lifespan of patients with ALS are controversial.

Example 2: Pharmacology

As an antagonist of glutamate release, riluzole protects against various glutamate toxicity models in vitro and animal models of neurodegenerative diseases, suggesting a potential neuroprotective effect against excitotoxicity.
However, its clinical effectiveness in the relevant neurodegenerative conditions is limited.

Example 3: Health Care Scenario

Riluzole provides the only treatment approved by the US FDA for ALS, though its efficacy has yet to be proven definitively due to the disease's heterogeneity and natural history.
Research indicates that riluzole slowed the decline of ALS patients in terms of physical strength, but had no effect on lung function.

Example 4: Neuroscience Study

The exact mechanism of action of riluzole in ALS involves not only the prevention of glutamate release triggered by damage to motoneurons but also other features such as oxoticity and mitochondrial dysfunction.

Example 5: Pharmaceutical Report

In clinical trials, riluzole has been shown to alleviate subjective symptoms such as pain and spasticity in ALS.
However, a separate report highlights the potential of a combination therapy that pairs riluzole with NMDA receptor antagonists to treat ALS models in animals.