"Ribociclib" Pronounce,Meaning And Examples

"Ribociclib" Meaning

Ribociclib is a medication used in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is a selective, oral medication that acts as a cyclin-dependent kinase (CDK) 4 and 6 inhibitor. It works by preventing cyclin-dependent kinases 4 and 6 from dividing cells that have abnormal numbers of chromosomes. This can help slow down the growth and spread of cancer cells in the body.

"Ribociclib" Examples

Ribociclib Usage Examples

Medical Research

Ribociclib is used in medical research as a potential therapeutic target for the treatment of hormone receptor-positive (HR+) metastatic breast cancer. Studies have shown that ribociclib, in combination with letrozole, can improve progression-free survival in women with HR+, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer.

Clinical Trials

In a Phase III clinical trial, ribociclib was compared to placebo with letrozole in postmenopausal women with HR+, HER2-negative metastatic breast cancer. The results showed that ribociclib improved progression-free survival and reduced the risk of disease progression compared to the placebo group.

Pharmaceutical Industry

Ribociclib is being developed by Novartis as a kinase inhibitor for the treatment of HR+, HER2-negative advanced breast cancer. The US FDA has approved ribociclib under the brand name Kisqali for this indication.

Academic Articles

The journal article published in the New England Journal of Medicine highlighted the efficacy of ribociclib in combination with letrozole in postmenopausal women with HR+, HER2-negative advanced breast cancer. The study demonstrated a statistically significant improvement in progression-free survival and affected patient outcomes.

FDA Approval

The US FDA granted accelerated approval to ribociclib as a treatment for HR+, HER2-negative advanced or metastatic breast cancer in 2017.