"Dihydrofolate" Pronounce,Meaning And Examples

"Dihydrofolate" Meaning

Dihydrofolate (DHF) is a vitamin B9 compound that is produced during the metabolism of folate. It is a intermediate product of the folate biosynthetic pathway and can be reconverted to tetrahydrofolate (THF), the active form of folate, through the action of the enzyme dihydrofolate reductase. DHF is an important precursor in the biosynthesis of purines, pyrimidines, and amino acids, and its deficiency can lead to anemia and other disorders.

"Dihydrofolate" Examples

Usage Examples for "Dihydrofolate"

1. Biological Context

In the process of folate metabolism, dihydrofolate is an intermediate compound that can be converted back to tetrahydrofolate through the enzyme dihydrofolate reductase.

2. Medical Research

The study focused on the effects of dihydrofolate on the efficacy of antifolate chemotherapy agents in treating certain types of cancer.

3. Biochemistry Textbook

Dihydrofolate is a critical intermediate in the synthesis of thymidylate from 5,10-methylenetetrahydrofolate, allowing the nucleotide pool to be maintained during rapid cell growth.

4. Peer-Reviewed Article

The team's research revealed that dihydrofolate production was significantly impaired in patients with genetic defects in the folate pathway, leading to an increased risk of neural tube defects.

5. Clinical Setting

The physician prescribed a course of folic acid supplements to help restore normal dihydrofolate levels and alleviate symptoms of folate deficiency anemia in a patient with a prolonged pregnancy.

Note: Dihydrofolate is a bioactive compound that plays a crucial role in folate metabolism, and its usage is primarily limited to scientific and medical contexts.