"Desmogleins" Pronounce,Meaning And Examples

"Desmogleins" Meaning

Desmogleins are a family of calcium-dependent cell adhesion molecules that play a crucial role in the formation and maintenance of desmosomes, which are structures that help to hold epithelial cells together. They are a key component of the desmosomal complex, along with desmocollins, plakoglobin, and plakophilin. Desmogleins help to create a strong adhesive bond between adjacent cells, which is important for maintaining the integrity of epithelial tissues and preventing them from separating. Abnormalities in desmoglein expression or function have been implicated in several skin and other disorders, including psoriasis, pemphigus, and junctional epidermolysis bullosa.

"Desmogleins" Examples

Usage Examples of Desmogleins

Example 1: Medical Context

In autoimmune bullous disease, the antibodies target desmogleins, a type of calcium-binding protein that plays a crucial role in the formation of desmosomes.

Example 2: Scientific Research

The study focused on the expression of desmogleins in human skin, specifically examining their role in maintaining the integrity of the epidermal layer.

Example 3: Medical Journal Article

The diagnosis of pemphigus vulgaris was confirmed through immunofluorescence microscopy, which revealed the presence of IgG antibodies against desmogleins 1 and 3.

Example 4: Academic Paper

Desmogleins are transmembrane proteins that facilitate cell-cell adhesion by forming desmosomal complexes, and defects in these proteins have been linked to various dermatological disorders.

Example 5: Research Paper Abstract

This study investigates the correlation between desmogleins levels and the severity of skin lesions in patients with dermatitis herpetiformis, aiming to gain insights into the molecular mechanisms underlying this condition.